Vulvo-vaginal candidiasis is a common infection with a prevalence of around 75% in women, while the recurrent form of the infection characterized by at least 3 episodes each year affects up to 5 to 8% of all women. Although risk factors such as pregnancy, antibiotic use and diabetes are well known, the majority of the women with RVVC have no known risk factors. It is believed that genetic factors have an important role in the risk to develop the disease.
DNA and serum of a cohort of 120 women suffering from RVVC is currently available, from which both Illumina Immunochip SNP array and whole exome sequencing data is available (55X). The follow-up of this study will include both microbiome and functional tests in a cohort of RVVC patients.